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KMID : 1140120050100020124
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Cancer Prevention Research
2005 Volume.10 No. 2 p.124 ~ p.127
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Antimutagenic and Anticarcinogegnic Effects of Korean Pears
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Yang Mi-Hi
Park Chang-Hwan
Kim Dae-Joong
Jeong Heon-Sang
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Abstract
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We already reported that consumption of Korean pears had inverse association with level of urinary 1-hydroxypyrene (1-OHP), which is an exposure biomarker and metabolite of polycyclic aromatic hydrocarbons (PAHs). As PAHs include various carcinogens such as benzo(a)pyrene, our report showed the chemopreventive potential of Korean pears. Recently, we studied effects of Korean-pears on PAH-induced mutagenicity and carcinogenicity, i.e. antimutagenic effects with MN (micronuclei) test and Comet assay, and anticarcinogenic effects with animals. Finally, we performed an intervention study with the pears in volunteers using toxicokinetic methods. As results, we found that Korean pears have antimutagenic, antioxidative, and anticarcinogenic effects against PAHs exposure and rapid excretion of parental PAHs. Therefore, the intake of pears after PAHs exposure such as BBQ is thought as an ideal lifestyle to prevent PAH-induced cancers.
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KEYWORD
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Polycyclic aromatic hydrocarbons (PAHs), 1-hydroxypyrene (1-OHP), Toxicokinetics, Korean pears, Antimutagenic, Antioxidative, Anticarcinogenic effects
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